Dopamine β-hydroxylase
Dopamine beta-hydroxylase; Dopamine beta-monooxygenase; Dopamine β-monooxygenase
Dopamine β-hydroxylase (Dopamine beta-hydroxylase, Dopamine beta-monooxygenase) is an enzyme that in humans is encoded by the DBH gene. Dopamine β-monooxygenase catalyzes the chemical reaction with 3 substrates of 3,4-dihydroxyphenethylamine, ascorbate, and O2, whereas its 3 products are noradrenaline, dehydroascorbate, and H2O. Dopamine β-hydroxylase belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. Dopamine β-hydroxylase participates in tyrosine metabolism. Dopamine β-hydroxylase has 3 cofactors: copper, PQQ, and Fumarate. Dopamine β-hydroxylase is in the catecholamine biosynthetic pathway. Dopamine β-hydroxylase has been shown to be associated with decision making and addictive behaviors such as alcohol and smoking, attention deficit hyperactivity disorder, and also with neurological diseases such as Schizophrenia and Alzheimer's.
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Dopamine β-hydroxylase Related Products (24)
Related Products (24)
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Antibodies (1)
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Zamicastat (Standard)
0 ImagesCat. No.: HY-106004RCAS No.: 1080028-80-3Synonyms: BIA 5-1058 (Standard)Zamicastat (Standard) is the analytical standard of Zamicastat (HY-106004). This product is intended for research and analytical applications. Zamicastat (BIA 5-1058) is a dopamine β-hydroxylase (DBH) inhibitor and can cross the blood-brain barrier (BBB) to cause central as well as peripheral effects. Zamicastat is also a concentration-dependent dual P-gp and BCRP inhibitor with IC50 values of 73.8 μM and 17.0 μM, respectively. Zamicastat reduces high blood pressure.
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Cuprizone (Standard)
0 ImagesCuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II). The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC).
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3-Allylphenol
0 Images3-Allylphenol is an inhibitor of dopamine β-hydroxylase with a Ki value of 12 mM.
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U-11634
0 ImagesU-11634 is an orally active dopamine β-hydroxylase noncompetitive inhibitor, with rat LD50 values of 1197 mg/kg (subcutaneous) and 524 mg/kg (oral). U-11634 blocks conversion of dopamine to norepinephrine and reduces norepinephrine levels in brain. U-11634 decreases food intake and spontaneous motor activity via dietary inclusion. U-11634 induces thyroid toxicity and inhibits pregnancy. U-11634 inhibits deciduomata formation in intact and steroid-treated rats, with no reversal by progesterone or oestradiol. U-11634 can be used for pregnancy.
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